Nurse-led Respiratory Syncytial Virus Immunisation

Nurse-led Respiratory Syncytial Virus Immunisation Respiratory syncyital virus in pre-term babies. Setting up a nurse led clinic to give Synagis (immunisation) with implications for nursing practice. From the neonatal nurses view point. Introduction The respiratory syncytial virus is identified as a labile paramyxovirus which produces a histologically characteristic effect of causing fusion of human cells in tissue culture – hence the term â€Å"syncytial†. It is commonly sub-classified into types A and B. The B strain is generally asymptomatic in the majority of the population whereas the A subtype tends to produce the more severe illnesses which tend to predominate in the majority of clinically significant outbreaks (Bar-on ME et al 1996). It has an incubation period of 4-6 days and the infection typically lasts from 7-14 days, but does occasionally last up to three weeks. If it becomes necessary to hospitalise a child with respiratory syncytial virus infection, the admission period is typically 5-7 days.(Hentschel J et al 2005) Contagion in the form of virus shedding is its highest levels during days 2-4 of the illness but the active viral particles will continue to be shed for up to 14 days after the clinical onset of symptoms. The respiratory syncytial virus is known to affect both upper and lower respiratory tracts although the most clinically significant manifestations arise in lower respiratory tract infections, bronchiolitis and pneumonia being perhaps the most significant. Bronchiolitis is a particularly severe illness in the pre-term infant by virtue of the fact that it causes very significant small airways obstruction. (Sigurs N et al 1995) The respiratory syncytial virus is currently the commonest identified cause of lower respiratory tract infections in children under the age of three world-wide. Serological studies have identified that, at least in the UK, that virtually all children will have had at least one episode of infection by the age of three. In the infant and neonate age groups, it is currently the numerically largest cause of both pneumonia and bronchiolitis (Krilov L R et al 1997), and is also thought to play a role (as yet not fully understood), in the aetiology of both asthma and chronic obstructive airways disease.(Pullan C R et al 1998) For those patients who have concurrent immunodeficiency states it is a very significant cause of both morbidity and mortality (Long C E et al 1995) Clinical presentation In our considerations here we shall confine our discussion to those clinical manifestations common in the neonatal group and accept that the comments made do not necessarily apply to those older children and adults who may also contract the virus. The respiratory syncytial virus is currently the commonest cause of pneumonia in young children with the greatest preponderance in the under three age range. (Jeng M-J et al 1997) The initial phases of an infection are generally characterised by symptoms of a transient upper respiratory tract infection such as runny nose, watery eyes and mild pyrexia. This typically progresses to produce symptoms of cough, wheeze (although this may be absent in the neonate), high pyrexia, dyspnoea, central cyanosis – characterised by a bluish tinge to the skin, lips and fingernails, increased respiratory rate and occasionally visible utilisation of the accessory muscles of respiration and sub-costal retraction, all of which indicate lower respiratory tract involvement. (Brunell P A 1997). In severe cases it can progress to the point of respiratory failure. In the context of our discussion here, these developments can be extremely dangerous in the pre-term infant who has significantly smaller airways than older children or adults, and also less in the way of respiratory reserve, so that any embarrassment of the respiratory function is of proportionally greater clinical significance. (Graham S M et al 2002) Particular risk factors for a severe bout of the disease are: Prematurity Young age (especially those less than six weeks old) Pre-existing heart conditions (congenital malformations) Pre-existing lung conditions (bronchopulmonary dysplasia and cystic fibrosis ) Immune system malfunction Low socio-economic status and especially those who live in Overcrowded housing conditions Passive exposure to cigarette smoke Day care or childcare attendance Presence of older children in the same household Lack of innate immunity from failure to breast feed. (after Thompson et al. 2003) Mode of infection After each bout of infection the body develops a degree of immunity to the virus. This is less of a factor in the neonate, whose immune system has not developed to the same degree as in the older child. In the pre-term infant , the immune response is (in practical terms) almost non-existent. In any event the immunity is never complete as the virus is capable of subtle mutations of its protein coat which allows it to partially evade the immune system. Re-infections are common but they do tend to be less severe than the original attack. (Panicar J, et al 2004) The mode of spread is through droplet spread and from direct contact with infected nasal or oral fluids. It can enter the body most easily through the epithelial surfaces of the eyes and nose. Epidimiology The respiratory syncytial virus produces characteristic patterns of infection which are epidemics of up to five months duration. They typically occur in the winter months and records show (since 1990) that they typically begin in the time span between October to mid-December with a marked peak in January and February. In the UK, the respiratory syncytial virus is responsible for about 125,000 episodes of hospitalisation (Leader S et al 2002).and about 2,500 deaths (NCHS 2002). These factors are of particular importance in our considerations when we are considering the timing of any protection programme. These figures translate into the fact that 20% of all hospital admissions for lower respiratory tract infections are due to respiratory syncytial virus infections, and if looked at as an annual incidence rate, admission for respiratory syncytial virus infection is currently 28.3 per 1,000 infants and 1.3 per 1,000 for children under the age of 4 years. (Muller-Pebody B et al 2002) The highest rate of clinically significant infection occurs at ages between 2 and 6 months with a significant peak in the 2-3 month age range. Respiratory syncytial virus is typically brought into the home by an older (school age) child who then passes it onto the younger child in the family. In child care and crà ¨che facilities it is quite common to observe 100% infection rates in both children and staff. On a practical note, respiratory syncytial virus infection has also been seen to spread throughout a hospital environment infecting patients and staff alike. (Shay, D K et al 2001), We shall specifically consider the implications of vaccination later in this essay, but there are other issues of prevention that require examination. We have already discussed the mode of common infection through the respiratory and ocular epithelial surfaces. It follows that there are certain measures which, while not eradicating the possibility of spread, will certainly help to reduce it. In the home environment, it is sensible to frequently wash hands after coming into contact with nasal or oral secretions and before handling a young child. Frequent handwashing will reduce the risk of contamination by direct spread. School age children should be kept as separate as practically possible from a neonate if they have symptoms of a â€Å"cold†. Sneezing into a handkerchief will also help to reduce the possibility of droplet transmission. In its droplet form, the virus will live on household surfaces for many hours and is therefore still capable of transmission. In terms of the work of the neonatal community nurse, such patient education should be seen both as part of an empowerment and education programme every bit as much as a prophylactic measure for the neonate. (Hogston, R et al 2002). In the more controlled environment of a hospital, it is possible to institute barrier measures if there is significant risk such as the immuno-compromised patient or the child at risk with congenital heart disease. Frequent pre-touching hand washing is essential to help prevent cross transmission (Ng D K et al 2000). Specific preventative treatments Palivizumab ( or Synagis – Trade name) is a medication that is commonly given to infants at highest risk of complications of respiratory syncytial virus infection, for example those who were born prematurely or those with chronic heart and lung disease. It is given by monthly injection through the at-risk winter months and provides significant levels of protection. This protection however, is comparatively short lived and has to be repeated on a yearly basis until the child is judged to be no longer at high risk of significant sequelae of infection. (PPTI 2005). It is also extremely expensive. (see on). Palivizumab is the first of what may become a series, of monoclonal antibodies, which have been developed to specifically target and combat one specific infection. Its current indications include prevention of serious lower respiratory tract disease caused specifically by the respiratory syncytial virus. There are currently a number of papers that have studied its safety and efficacy in a number of situations such as bronchopulmonary dysplasia (BPD), infants with a history of premature birth (≠¤35 weeks gestational age), and children with hemodynamically significant CHD. (Meissner H C et al 1999), Technically it is a humanised monoclonal antibody of IgG1k type which is produced by recombinant DNA methods. It targets an A antigenic site of the F-protein covering of the virus. It is primarily derived from human antibody sequences and has two light and two heavy chains with a molecular weight of about 148,000 Daltons. The viability of nurse-led respiratory syncytial virus immunisation programme. >From the literature and the evidence that we have presented so far we can point to the fact that the respiratory syncytial virus is a significant risk to neonates, especially those who have significant risk factors for the development of lower respiratory tract complications. (Berwick D 2005) Although we specifically have not considered treatment in this essay, we should note that, in the context of a discussion on the role of prophylaxis, that the treatments available for neonate infection with respiratory syncytial virus are severely limited. In the words of Jon Friedland, an eminent professor of infectious diseases in London: Treating respiratory syncytial virus bronchiolitis remains a good example of therapeutic nihilism — nothing works except oxygen. Adrenaline, bronchodilators, steroids, and ribavirin all confer no real benefit. (quoted in Handforth J et al 2004) If we accept that this is the case and we also accept the significant morbidity and mortality rates quoted earlier in this essay, then it clearly makes sense to consider the role of prophylaxis in respiratory syncytial virus infections. It clearly therefore also makes sense to consider what active measures can be taken in order to try to reduce the possibility of infection or prevent the damaging and serious sequelae of infection. Sadly, this is far from straightforward. One could reasonably hope that a immunologically based vaccine would have been developed to help with this problem. Despite the fact that the first formalin inactivated respiratory syncytial virus vaccine was developed over forty years ago, progress in this field appears to have been painfully slow. Recently published literature on the subject of the effect of vaccines against respiratory syncytial virus found that there was no significant benefit conferred in terms of preventing either the infection or the complications. (Simoes E A et al 2001). We should note that this was not a small study but a meta-analysis of five major studies on the subject and therefore has considerable weight if we are considering an evidence base for our findings. (Green J et al 1998). If we accept the premise that a successful respiratory syncytial virus vaccine should be able to prevent severe lower respiratory tract disease and the morbidity consequent upon it, and should also ideally protect against both A and B strains of the virus, we would also have to postulate that it would have to be given directly after birth in order to prevent immediate primary infection form the environment. In general terms, this presents the nub of the problem as neonates have very poorly developed immune response mechanisms and the bulk of their immunity is passively derived form the trans-placental maternal antibody production and the immunoglobulins present in the maternal milk. (Kim H W et al 1969). Active immunisation in very early life proves to be fruitless, as the immature neonatal immune system cannot generally produce either an adequate T-cell response or effective antibody levels. It is also the case that the maternal antibodies themselves, also interfere with the infant’s ability to mount an antibody response of its own. (Clements M L et al 1996) In order to combat these problems there are a number of immunological strategies currently under investigation. One strategy is to vaccinate the mother during the third trimester in order to try to boost the naturally occurring antibodies and thereby increase the natural passive immunity. This is unlikely to give significant immunity beyond the first six weeks of birth unless the child is breast fed, in which case the immunity would last for longer (see below). It would however, have the advantage of protecting the most vulnerable individuals at a critical time. Initial trials of this method using a purified F protein subunit vaccine was found to be safe in a trial of 35 third trimester vaccinations. (Munoz FM et al 2003). The trial showed a disappointing, but detectable, response and the infants had increased IgG against respiratory syncytial virus up until 9 months of age. Clearly this strategy would be ineffective against children born with a significant degree of prematurity and who therefore, are at greatest risk A second approach was tried with live attenuated genetically modified vaccine. This approach was found to work in adults and older children but could not be sufficiently attenuated to produce a safe and sufficient response in neonates. (Piedra P A 2003). The third approach was to try live recombinant viral vectors which expressed respiratory syncytial virus proteins. Thus far, the results have been disappointing both in terms of immunogenicity and there are also safety concerns with iatrogenic oncogene activation. (Haller A A et al 2003) In terms of our potential nurse run clinic, all of these options have very significant drawbacks and none are therefore likely to represent a realistic immunisation option. Clarke (S J et al 2000) suggest that although huge strides have been taken with a number of vaccine products – especially the live attenuated vaccines, it will probably be a minimum of another decade before routine effective vaccination becomes widely available. It is perhaps because of this failure to present a solution of a vaccine that has caused researchers to examine other avenues of investigation for workable prophylactics. A line of investigation into passive immunity with IV hyperimmune globulins against respiratory syncytial virus has shown positive results in initial trials against preventing severe forms of respiratory complications in high risk children (Groothuis J R et al 1999). This particular formulation can only be given intravenously and therefore is of limited use outside of a hospital environment. It is clearly of no use in a community setting. The other line of passive immunity has developed into the intramuscular form of IgG humanised monoclonal antibody described above (palivizumab). Clinical trials already published have already shown that monthly injections of palivizumab in high risk infants have been able to reduce the hospital admissions for respiratory syncytial virus-related disease by more than 50% (IRSVSG 1998). This was a well designed double-blind placebo controlled randomised study and, in addition to apparently demonstrating its efficacy, it also showed an impressive safety record. This particular formulation appears to have a very good side-effect profile and clinical experience appears to confirm the initial trial results. Given the fact that respiratory syncytial virus places a heavy financial and economic burden on the NHS, a 50 % reduction in these levels is quite substantial. Cost-effectiveness is clearly a major question in any consideration of a national vaccination programme and studies elsewhere in Europe, (Roeckl-Wiedmann I et al 2003) have called into question the costings and have therefore also called into question the need for further evaluation. These considerations are given further credence if we consider the fact that if we take as a marker the number of hospital laboratory reports of respiratory syncytial virus, there appears to be a marked downward trend in the UK between 1990 and 2003. (Fleming D M et al 2003). It may be that there are other active factors here such as changes in clinical or laboratory practice, but it would appear to reflect a definite downward trend. This comment is actually given further credence when one considers the epidemiological data from the primary health care sources which also show a fall in acute respiratory infections over the same period. (Neuzil K M et al 2000) Passive immunisation is currently considered to be the best option in terms of providing immunity in the community although many authorities consider that it is currently only an option for the high risk infant. In the terms of our consideration here for a nurse run immunisation clinic, we should consider a set of guidelines, (that were actually produced in the USA), which could be adopted as they are based on the current best evidence available. (AAP 2003) The guidelines suggest that passive immunisation (palivizumab ) should be currently considered for premature infants born at less than 32-35 weeks gestation or for infants younger than 2 years with chronic lung disease. Although this is clearly a rational view, we have to note that it is based upon American statistics and American costings and is applicable primarily to American culture. It does not imply that the recommendations are necessarily transferable to the UK situation. The NHS has been more cautious. The current NHS guidelines were considered and formulated by the joint committee on vaccination and immunisation of the Department of Health. (JCVI 2002). Their report notes that: Palivizumab seems safe, well tolerated, and effective in reducing admissions to hospital, but it remains very expensive, at a cost of around  £2500 for five doses over the season for respiratory syncytial virus. In the UK, the statistics seem to suggest that readmission rates associated with respiratory syncytial virus infection-related bronchioliitis show that palivizumab is only cost effective if it is used in infants born prematurely with chronic lung disease and receiving oxygen at home (which is actually a very expensive undertaking in any event). (Feltes T F et al 2003). If this opinion is taken in conjunction with the suspicion that the rates of respiratory syncytial virus infection are actually falling, this will actually weight the cost-effectiveness argument further against the use of palivizumab. It is noted that a more recent study of palivizumab in infants who have congenital heart disease has been completed, but the information collected is insufficient in terms of readmission rates, morbidity and cost-benefit analysis, to allow a confident recommendation for use in this population. (Feltes T F et al 2003) The neonatal nurse’s viewpoint. In this essay we have considered much of the current literature on the subject of community immunisation for respiratory syncytial virus. There is little doubt that the virus represents a significant threat to a small proportion of neonates and a minor threat to the rest. (Crowe JE Jr 1995). It is also clear from the evidence that the prospect of active immunisation of the at risk groups has been aggressively pursued over a time scale of about four decades with very little in the way of positive practical results. In essence, this means that the only realistic prospect of giving the at-risk neonate a degree of protection against the respiratory syncytial virus, is by means of increasing the levels of passive immunity. We have considered the role of the only viable therapeutic agent in this area (palivizumab), and have come to the conclusion that the evidence base for its use is sound if it is given on a monthly basis through the winter months when the at risk populations are at greatest risk of significant morbidity, and indeed mortality. Against this statement we have to weight the cost-effectiveness of what is a very expensive agent. (Handforth J et al 2000). The neonatal community nurse therefore finds herself ideally placed to act as the gatekeeper in this role. By virtue of her position of having direct contact with each of the neonates in her community, she is probably the most optimally places member of the primary healthcare team to assess and oversee the administration of palivizumab to those at greatest risk. (Scally G et al 1998) The mechanics of the enterprise will inevitably vary from practice to practice, but the elements of any recall system will be an up to date age/sex register, a forward planning facility and good communications with the antenatal services so that prospective candidates can be assessed at the earliest opportunity. The multidisciplinary nature of the modern primary healthcare team is ideal for communication of this nature and the neonatal nurse should be able to optimally utilise the recall facilities of the practice in order to ensure maximal compliance once the decision to treat has been made. (Yura H et al 1998) On the positive side there is the fact that Nurse led clinics, in general terms, have been proven to work both effectively and efficiently in many other areas. On the negative side we have the practical situation that the current recommendations from the Joint Committee on Vaccination and Immunisation that the current evidence base supports the view that palivizumab should only be offered to babies in the Group I classification, which currently includes babies under the age of two years with severe chronic lung disease, on home oxygen during the RSV season. This represents about 500 babies a year nationally. Common sense would indicate that there is absolutely no practical rationale for setting up any form of clinic in primary care for this number of babies on a national basis. Even if this recommendation was extended to include those babies in Group II (those with chronic lung disease but not on home oxygen), this would only add another 1000 to the national total and again, clearly there would be absolutely no rationale for setting up a local clinic base for this type of work load. (Netten A et al. 2000) The Committee’s reasoning for offering palivizumab to the Group I babies was on the evidence that it would be likely to reduce hospitalisation by a factor of 40% and thereby be cost effective. The Committee also suggested that these guidelines should be reviewed if a more effective and cheaper vaccine became available. If we consider, for the sake of argument, that such a vaccine has become available and that it is both practical and National policy to set up such vaccination clinics, we can consider the leads given by papers that report experiences in other areas of childhood vaccination. Nesbitt (A et al. 1997) give a very informative overview of the practical difficulties involved in setting up a Hepatitis B vaccination clinic. They point to the problems of trying to reach the most vulnerable and potentially isolated individuals in the community and highlight the need for specific nurse initiated home visits to the persistent absentees to the clinic. (Nesbitt A et al. 1995) They also highlight the difficulties in trying to get a level of immunity in a population that is constantly turning over. It requires a very high degree of vigilance on the part of the nurse running the clinic to ensure that all new arrivals are incorporated into the recall system with complete efficiency and without delay. On a slightly tangential subject, the whole issue of the nurse-led clinic was reviewed and assessed for overall effectiveness and cost effectiveness by Raftery (J et al. 2005). This paper demonstrated, beyond doubt that nurse led clinics could be both effective and very cost effective. This particular paper looked at the role of the clinic in the prevention of heart disease in the adult population, which is clearly not directly applicable to our considerations here, but the important relevant considerations are that the autonomous nurse led clinic can work very effectively with auditable results that can demonstrate both positive health benefits and an efficient and cost-effective use of a nurse’s time. (Polsky D et al. 1997) One of the interesting points raised in this paper which was also directly transferable to a nurse led immunisation clinic was that the increased costs noted also included an element for increased prescribing for intercurrent morbidity that was discovered at the time of the assessment. This is a factor that is likely to be translated into increased costings for the vaccination clinic, as many mothers are likely to save up questions and minor degrees of pathology if they know that they are having an appointment with the practice nurse. (Lancaster T 2003). This may well be translated into increased prescribing costs. Taking a holistic view however, one would hope that these costs would not be incurred without good reason and therefore one could conclude that it would be for the greater good of the patient in the long run and therefore presumably justified. (Benger J R et al. 2005) Considering all of these issues one can see that the viability of the nurse led clinic, certainly in the areas of RSV vaccination, is totally dependant on the development of an effective and cheaper vaccine. At this point in time, the recommendations do not support the logistics of a nurse led clinic for palivizumab although it is clear that the neonatal nurse should be the prime source of the palivizumab vaccination, the numbers involved support the specific identification and targeting of the Group I babies. References AAP 2003 American Academy of Pediatrics. Respiratory syncytial virus. In: Pickering LK, ed. Red Book: 2003 Report of the committee on infectious diseases. 26th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2003: 523-8. Bar-on ME, Zanga JR. 1996 Bronchiolitis. Prim Care. 1996;23:805-819. Benger J R, Hoskins R 2005 Nurse led care: Nurses are autonomous professionals delivering expert care BMJ 2005 330: 1084. Berwick D 2005 Broadening the view of evidence-based medicine Qual. Saf. Health Care, Oct 2005; 14: 315 316. Brunell PA. 1997 The respiratory season is upon us. Infectious Diseases in Children. Thorofare, NJ: Slack Inc; 1997;10(1):5. Clark SJ, Beresford MW, Subhedar NV, Shaw NJ. 2000 Respiratory syncytial virus infection in high risk infants and the potential impact of prophylaxis in a United Kingdom cohort. Arch Dis Child 2000;83: 313-6 Clements ML, Makhene MK, Karron RA, Murphy BR, Steinhoff MC, Subbarao K, et al. 1996 Effective immunisation with live attenuated influenza A virus can be achieved in early infancy. J Infect Dis 1996;173: 44-51. Crowe JE Jr. 1995 Current approaches to the development of vaccines against disease caused by respiratory syncytial virus (RSV) and parainfluenza virus (PIV): a meeting report of the WHO Programme for Vaccine Development. Vaccine 1995;13: 415-21. Feltes TF, Cabalka AK, Meissner HC, Piazza FM, Carlin DA, Top FH, et al for the Cardiac Synagis Study Group.2003 Palivizumab reduces hospitalisation due to respiratory syncytial virus in young children with haemodynamically significant congenital heart disease. J Pediatrics 2003;143: 532-40 Fleming DM, Ross AM, Cross KW, Kendall H. 2003 The reducing influence of respiratory tract infection and its relation to antibiotic prescribing. Br J Gen Pract 2003;53: 778-83. Graham SM, Gibb DM. 002 HIV disease and respiratory infection in children. Br Med Bull 2002;61: 133-50 Green J, Britten N. 1998 Qualitative research and evidence based medicine. BMJ 1998; 316: 1230-1233 Groothuis JR, Simoes EAE, Levin MJ, Hall CB, Long CE, Rodriguez WJ. 1999 Prophylactic administration of respiratory syncytial virus immune globulin to high-risk infants and young children. N Engl J Med 1999;329: 1524-30 Haller AA, Mitiku M, Macphail M. 2003 Bovine parainfluenza virus type 3 (PIV3) expressing the respiratory syncytial virus (RSV) attachment and fusion proteins protects hamsters from challenge with human PIV3 and RSV. J Gen Virol 2003;84(Pt 8): 2153-62 Handforth J, Friedland JS, Sharland M. 2000 Basic epidemiology and immunopathology of RSV in children. Paediatr Respir Rev 2000;1: 210-4 Handforth J, Mike Sharland, and Jon S Friedland 2004 Prevention of respiratory syncytial virus infection in infants BMJ, May 2004; 328: 1026 – 1027 Hentschel J Berger T M Tschopp A et al 2005 Population-based study of bronchopulmonary dysplasia in very low birth weight infants in Switzerland. Eur J Pediatr 2005 May;164(5):292-7. Hogston, R. Simpson, P. M. (2002) Foundations in nursing practice 2nd Edition, London: Palgrave Macmillian. 2002 IRSVSG 1998 The Impact-RSV Study Group. Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. Pediatrics 1998;102: 531-7 Jeng M-J, Lemen RJ. 1997 Respiratory syncytial virus bronciolitis. Am Fam Physician. 1997;55:1139-1146. JCVI 2002 Joint Committee on Vaccination and Immunisation. Minutes of the meeting held on 1 November 2002. www.doh.gov.uk/jcvimins01nov02.htm (accessed 31.3.06) Kim HW, Canchola JG, Brandt CD, Pyles G, Chanock RM, Jensen K, et al. 1969 Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol 1969;89: 422-34 Krilov LR, Mandel FS, Barone SR, Fagin JC and The Bronchiolitis Study Group. 1997 Follow-up of the children with respiratory syncytial virus bronchiolitis in 1986 and 1987: potential effect of ribavirin on long term pulmonary function. Pediatr Infect Dis J. 1997;16:273-6. Lancaster T. 2003 The benefits of nurse led secondary prevention clinics continued after 4 years. Evid Based Med 2003;8: 158 Leader S. Kohlhase K. 2002 Respiratory syncytial virus-coded pediatric h

Rampant Child Labor

â€Å"The children are the future of our nation.† This famous line of Dr. Jose Rizal has gained prominence especially among policy makers in their quest to develop and implement laws and programs that will propel the total development of a nation's millions of children. I personally agree with Rizal's vision since each child is a potential contributor in the improvement of society. A child may seem insignificant in determining the status or condition of a society, but collectively it is a major determinant in a society's progress. Unfortunately, in the Philippines, street children are victims of trafficking for illegal employment and prostitution. This is due to the poverty, hunger and abuse which a street child experiences at an early age. Street children become more susceptible to these illegal treatments because of the lack of education and awareness toward their society, environment and human rights. As a result, they tend to disregard education and start working at an early age to be able to help themselves as well as their family financially. Child labor is the illegal employment of children below the age of 15, where they are not directly under the sole responsibility of their parents or legal guardians. Furthermore, the child's work endangers their life, safety, health and morals or it hinders them from schooling. It also includes the situation of children below the age of 18 who are employed in hazardous occupations. In the 1997 Asian consultation on Child Labor, representatives of government and non-government organizations, as well as the child workers themselves tallied the most intolerable forms of child labor. These include the following: prostitution of children and similar work in the entertainment industry, children used as soldiers, mining and quarrying, construction work, deep-sea fishing, smuggling of illegal substances, scavenging and pyrotechnics. The negative impact of child labor often causes irreparable damage to the child's physical and psychological development. Children who start working at an early age most likely suffer from respiratory diseases, deaths, poor nutrition, physical health hazards, sexually transmitted disease and anti-social behavior. In addition, they tremendously reduce educational opportunities, which later leads to dropping-out and illiteracy. Since they have abandoned their educational responsibilities, it is difficult for them to stop working. Today, because of the increase in child labor, the basic minimum age of employment in the Philippines is contained in Republic Act 7658. The minimum age of employment for hazardous is contained in the Labor Code. These two laws are complemented by other national laws containing some provisions. Since 1988, the Government of the Philippines, in partnership with UNICEF among others, has established programs for child labor which seeks to abolish exploitative child labor and provide protection, healing and recovery for child workers. We, students who receive adequate education can help in reducing child labor through many means. We could teach young children about the value of education since they will understand us better because we are basically the same age. For instance, in child-to-child projects, we can try to build a child's self-esteem and self-worth. We could also help generate income for poor families and organizations. Furthermore, by simply taking care of our environment which includes households, school grounds, or our community, we are helping by giving children a healthier atmosphere for growing up. This would reduce sickness and reflect on our physical outlook. These are just some of the many simple ways wherein we could help street children uplift their living condition.

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Core Values Of Civilization - 1005 Words

Since the beginning of time people have been in awe at the formation of civilization. Books have been written, articles have been published, and even Sid Meier created the video game Civilization surrounding this concept. In the game, players are tasked with not only establishing and maintaining a civilization but as well as determining the core values and characteristics of the civilization in question. The core values of civilization are the use of tools and technology for life enhancement, social and political organization, and an agreed upon settlement and language. The use of tools and technology is one of the basic characteristics of civilization in that it allows the civilization the better itself. A common representation in†¦show more content†¦In the earliest Indian civilization technology allowed the massive civilization of over 100,000 people to live together through the use of sewage canals to transport waste from the houses to larger canals. This concept has been used even in modern times. Technology allowed civilizations to not only better themselves but establish a legacy for the civilization to follow and last even until today. With every establishment and group there must be a sense of organization both political and social. Just as school clubs have officers, civilizations have leaders that spearhead the group. In the Stone Age, tribal leaders led the group from place to place. This nomadic lifestyle relied on experience to guide the search for food. Once settling into an agricultural lifestyle, social classes began to form based on success harvests and land ownership. In Mesopotamian culture, organization was built not only around social hierarchy with famous rulers being Sargon the Great and Hammurabi but religiously as pyramids known as Ziggurats were built to worship and sacrifice to the Gods. The greatest implementation of organization is found in ancient Egypt with not only the society being structured with the pharaoh ruling the nation and lower levels of aristocracy but with the emphasis being focused on religious efforts. In Egypt, the pharaoh was not onlyShow MoreRelatedThe Battle Of Civiliz ations By Samuel P. Huntington1302 Words   |  6 PagesThere came the competition of global dominance in the modern era, over four hundred years of Western civilizations interacting, competing, and fighting. The Cold War which lasted over forty years of the Twentieth Century changed the course of the world and in the end, ushered in a new world order. In his article â€Å"The Clash of Civilizations†, Samuel P. Huntington captured what the world was like at the end of the Cold War. The question during the Cold War was â€Å"What side are you on?† became now â€Å"WhoRead MoreComparison of Civilizations in the Ancient World Essay983 Words   |  4 PagesEarly civilization consisted of core values that defined the communities that resided within it. These communities were driven by numerous factors in which would decide the overall outcome of the civilization. Geography, social and economic values, and they’re culture all played an important role in the makeup of these civilizations. Mesopotamia was a successful farming community early on. Utilizing the Tigris and Euphrates rivers this community was able to create a successful way of farming throughRead MoreSigmund Freud s Civilization And Its Discontents1582 Words   |  7 PagesSigmund Freud, in his book Civilization and Its Discontents, contests that humans are subject to savage, animalistic instincts. 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Authors of the article, “Climate and the Collapse of Maya Civilization”, which include Gerald Haug, Detlef Gà ¼nther, Larry Peterson, Daniel Sigman, Konrad Hughen, and Beat Aeschlimann propose a theory that the Mayans collapsed because of an extended dry period between 760 and 910 A.D. These scientists set out find the answer as to why the Maya civilization collapsed. This question is fairlyRead MoreThe Influences On Western Civilization1559 Words   |  7 PagesThe Influences on Western Civilization by the Hebrew-Christian and Greco-Roman Traditions Western Civilization, as it is known today, is a coalescence of various cultures, ideologies, and practices that have been preserved over centuries of human life. Although a countless number of societies have influenced Western Civilization, Hebrew-Christian civilizations and Greco-Roman civilizations have been the two most influential. Both of these civilizations and their traditions have left equally deepRead MoreThe Day After 911: Changes of the United States963 Words   |  4 Pagesâ€Å"The Day after 911: Changes of the United States† The Middle East is one of the birthplaces of human kind’s civilization. Since the Ancient Egypt, Sumer, the Arab Empire, Turkey Empire, or even to present day, the Middle East has always been a valuable strategic point for not only because of its geographic location but also it full of petroleum and nature gas. According the OPEC (Organization of the Petroleum Exporting Countries) that 66% of the global oil reserves are in the Middle East andRead MoreLord Of The Flies Character Analysis1264 Words   |  6 Pagesorder and morality. In the end of the novel, Ralph starts to lose the specific character traits that define him as a productive leader as the boys around him turn savage and civilization fades from their society. As the novel progresses, Ralph takes a turn for the worse as he starts to succumb to the setting, forget his core principles, and feel the temptation of savagery. When Ralph first arrives on the island, he is a civilized leader. When he learns that no adults inhabit the island